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Publications (en anglais)

  1. Articles scientifiques
  2. Livres
  3. Mémoires

 

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1. Articles scientifiques

  •  

    Flexoelectric fluid membrane vesicles in spherical confinement

    Niloufar Abtahi, Lila Bouzar, Nadia Saidi-Amroun, Martin Michael Müller

    The morphology of spherically confined flexoelectric fluid membrane vesicles in an ex- ternal uniform electric field is studied numerically. Due to the deformations induced by the confinement, the membrane becomes polarized resulting in an interaction with the external field. The equilibrium shapes of the vesicle without electric field can be clas- sified in a geometrical phase diagram as a function of scaled area and reduced volume [1, 2]. When the area of the membrane is only slightly larger than the area of the con- fining sphere, a single axisymmetric invagination appears. A non-vanishing electric field induces an additional elongation of the confined vesicle which is either perpendicular or parallel depending on the sign of the electric field parameter. Higher values of the surface area or the electric field parameter can reduce the symmetry of the system leading to more complex folding. We present the resulting shapes and show that transition lines are shifted in the presence of an electric field. The obtained folding patterns could be of interest for biophysical and technological applications alike.

     Fermer     Plus d'infos

    EPL, 131(1): 18001, 2020. Cf. aussi arXiv:2006.04475.

     


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    Isometric bending requires local constraints on free edges

    Jemal Guven, Martin Michael Müller, Pablo Vázquez-Montejo

    Résumé     Plus d'infos

    Math. Mech. Solids, 24: 4051, 2019. Cf. aussi arXiv:1904.05855.

     


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    Helical Superstructure of Intermediate Filaments

    Lila Bouzar, Martin Michael Müller, René Messina, Bernd Nöding, Sarah Köster, Hervé Mohrbach, Igor M. Kulić

    Résumé     Plus d'infos

    Phys. Rev. Lett., 122: 098101, 2019. Cf. aussi arXiv:1803.04691.

     


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    Vesicle dynamics in confined steady and harmonically modulated Poiseuille flows

    Zakaria Boujja, Chaouqi Misbah, Hamid Ez-Zahraouy, Abdelilah Benyoussef, Thomas John, Christian Wagner, Martin Michael Müller

    Résumé     

    Phys. Rev. E, 98: 043111, 2018. Cf. aussi arXiv:1810.04500.

     


  •  

    Confining a fluid membrane vesicle of toroidal topology in an adhesive hard sphere

    Lila Bouzar, Ferhat Menas, Martin Michael Müller

    Résumé     Plus d'infos

    IOP Conf. Series: MSE, 186: 012021, 2017.

     


  •  

    Squeezed helical elastica

    Lila Bouzar, Martin Michael Müller, Pierre Gosselin, Igor M. Kulić, Hervé Mohrbach

    Résumé     Plus d'infos

    Eur. Phys. J. E, 39: 114, 2016. Cf. aussi arXiv:1606.03611.

     


  •  

    How bio-filaments twist membranes

    Julien Fierling, Albert Johner, Igor M. Kulić, Hervé Mohrbach, Martin Michael Müller

    Résumé     

    Soft Matter, 12: 5747, 2016.

     


  •  

    Toroidal membrane vesicles in spherical confinement

    Lila Bouzar, Ferhat Menas, Martin Michael Müller

    Résumé     Plus d'infos

    Phys. Rev. E, 92: 032721, 2015. Cf. aussi arXiv:1509.00765.

     


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    Non-linear buckling and symmetry breaking of a soft elastic sheet sliding on a cylindrical substrate

    Norbert Stoop, Martin Michael Müller

    Résumé     Plus d'infos

    Int. J. Non-Linear Mech., 75: 115, 2015. Cf. aussi arXiv:1503.05030.

     


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    Crunching Biofilament Rings

    Julien Fierling, Martin Michael Müller, Hervé Mohrbach, Albert Johner, Igor M. Kulić

    Résumé     Plus d'infos

    Europhys. Lett., 107(6): 68002, 2014. Cf. aussi arXiv:1408.6787.

     


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    Confotronic dynamics of tubular filaments

    Osman Kahraman, Hervé Mohrbach, Martin Michael Müller, Igor M. Kulić

    Résumé     Plus d'infos

    Soft Matter, 10(16): pp. 2836-2847, 2014. Cf. aussi arXiv:1312.3106.

     


  •  

    Whirling skirts and rotating cones

    Jemal Guven, J. A. Hanna, Martin Michael Müller

    Résumé     

    New J. Phys., 15: 113055, 2013. Cf. aussi arXiv:1306.2619.

     


  •  

    Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo

    Leonela Amoasii, Karim Hnia, Gaëtan Chicanne, Andreas Brech, Belinda Simone Cowling, Martin Michael Müller, Yannick Schwab, Pascale Koebel, Arnaud Ferry, Bernard Payrastre, Jocelyn Laporte

    The sarcoplasmic reticulum (SR) is a specialized form of endoplasmic reticulum (ER) in skeletal muscle and is essential for calcium homeostasis. The mechanisms involved in SR remodeling and maintenance of SR subdomains are elusive. In this study, we identified myotubularin (MTM1), a phosphatase mutated in X-linked centronuclear myopathy (XLCNM), as a key regulator of phosphoinositide-3-monophosphate (PtdIns3P) levels at the SR. Mtm1 deficient mouse muscles and myoblasts from XLCNM patients exhibit abnormal SR/ER networks. In vivo modulation of MTM1 enzymatic activity in muscle using ectopic expression of wild-type or a dead-phosphatase MTM1 protein leads to differential SR remodeling. Active MTM1 is associated to flat membrane stacks, while dead-phosphatase MTM1 mutant promotes highly curved cubic membranes originating from the SR and enriched in PtdIns3P. Moreover, expression of the PtdIns3P binding module 2XFYVE also modified the SR shape at triads. Our findings, supported by the parallel analysis of the Mtm1- null mouse and in vivo study, reveal a direct function of MTM1 enzymatic activity in SR remodeling and a key role for its substrate PtdIns3P in promoting SR membrane curvature in skeletal muscle. We propose that alteration in SR remodeling is a primary cause of X-linked centronuclear myopathy. The tight regulation of PtdIns3P on specific membrane subdomains may be a general mechanism to control membrane curvature.

     Fermer     

    J. Cell Sci., 126(8): 1806, 2013.

     


  •  

    Dipoles in thin sheets

    Jemal Guven, J. A. Hanna, Osman Kahraman, Martin Michael Müller

    Résumé     Plus d'infos

    Eur. Phys. J. E, 36: 106, 2013. Cf. aussi arXiv:1212.3262.

     


  •  

    Fluid membrane vesicles in confinement

    Osman Kahraman, Norbert Stoop, Martin Michael Müller

    Résumé     Plus d'infos

    New J. Phys., 14: 095021, 2012.

     


  •  

    Petal shapes of sympetaleous flowers: the interplay between growth, geometry and elasticity

    Martine Ben Amar, Martin Michael Müller, Miguel Trejo

    Résumé     Plus d'infos

    New J. Phys., 14: 085014, 2012. Choisi pour les Highlights of 2012.

     


  •  

    Morphogenesis of membrane invaginations in spherical confinement

    Osman Kahraman, Norbert Stoop, Martin Michael Müller

    Résumé     Plus d'infos

    Europhys. Lett., 97(6): 68008, 2012. Cf. aussi arXiv:1201.2518.

     


  •  

    Conical instabilities on paper

    Jemal Guven, Martin Michael Müller, Pablo Vázquez-Montejo

    Résumé     Plus d'infos

    J. Phys. A: Math. Theor., 45(1): 015203, 2012. Cf. aussi arXiv:1107.5008.

     


  •  

    Interface-mediated interactions: Entropic forces of curved membranes

    Pierre Gosselin, Hervé Mohrbach, Martin Michael Müller

    Particles embedded in a fluctuating interface experience forces and torques mediated by the deformations and by the thermal fluctuations of the medium. Considering a system of two cylinders bound to a fluid membrane we show that the entropic contribution enhances the curvature-mediated repulsion between the two cylinders. This is contrary to the usual attractive Casimir force in the absence of curvature-mediated interactions. For a large distance between the cylinders, we retrieve the renormalization of the surface tension of a flat membrane due to thermal fluctuations.

     Fermer     Plus d'infos

    Phys. Rev. E, 83(5): 051921, 2011. Cf. aussi arXiv:1011.1221.

     


  •  

    Self-Contact and Instabilities in the Anisotropic Growth of Elastic Membranes

    Norbert Stoop, Falk K. Wittel, Martine Ben Amar, Martin Michael Müller, Hans J. Herrmann

    We investigate the morphology of thin discs and rings growing in circumferential direction. Recent analytical results suggest that this growth produces symmetric excess cones (e-cones). We study the stability of such solutions considering self-contact and bending stress. We show that, contrary to what was assumed in previous analytical solutions, beyond a critical growth factor, no symmetric e-cone solution is energetically minimal any more. Instead, we obtain skewed e-cone solutions having lower energy, characterized by a skewness angle and repetitive spiral winding with increasing growth. These results are generalized to discs with varying thickness and rings with holes of different radii.

     Fermer     Plus d'infos

    Phys. Rev. Lett., 105(6): 068101, 2010. Cf. aussi arXiv:1007.1871.

     


  •  

    Cell Model Approach to Membrane Mediated Protein Interactions

    Martin Michael Müller, Markus Deserno

    Résumé     Plus d'infos

    Prog. Theor. Phys. Suppl., 184: pp. 351-363, 2010.

     


  •  

    Hamiltonian formulation of surfaces with constant Gaussian curvature

    Miguel Trejo, Martine Ben Amar, Martin Michael Müller

    Résumé     Plus d'infos

    J. Phys. A: Math. Theor., 42(42): 425204, 2009.

     


  •  

    Local Membrane Mechanics of Pore-Spanning Bilayers

    Ingo Mey, Milena Stephan, Eva K. Schmitt, Martin Michael Müller, Martine Ben Amar, Claudia Steinem, Andreas Janshoff

    Résumé     Plus d'infos

    J. Am. Chem. Soc., 131(20): pp. 7031-7039, 2009.

     


  •  

    Elasticity Mapping of Pore-Suspending Native Cell Membranes

    Bärbel Lorenz, Ingo Mey, Siegfried Steltenkamp, Tamir Fine, Christina Rommel, Martin Michael Müller, Alexander Maiwald, Joachim Wegener, Claudia Steinem, Andreas Janshoff

    Résumé     Plus d'infos

    Small, 5(7): pp. 832-838, 2009.

     


  •  

    Conical Defects in Growing Sheets

    Martin Michael Müller, Martine Ben Amar, Jemal Guven

    Résumé     Plus d'infos

    Phys. Rev. Lett., 101(15): 156104, 2008. Cf. aussi arXiv:0807.1814.

     


  •  

    How paper folds: bending with local constraints

    Jemal Guven, Martin Michael Müller

    Résumé     Plus d'infos

    J. Phys. A: Math. Theor., 41(5): 055203, 2008. Cf. aussi arXiv:0712.0978.

     


  •  

    Contact lines for fluid surface adhesion

    Markus Deserno, Martin Michael Müller, Jemal Guven

    Résumé     Plus d'infos

    Phys. Rev. E, 76(1): 011605, 2007. Cf. aussi cond-mat/0703019.
    Choisi pour le Virtual Journal of Biological Physics Research.

     


  •  

    Balancing torques in membrane-mediated interactions: Exact results and numerical illustrations

    Martin Michael Müller, Markus Deserno, Jemal Guven

    Résumé     Plus d'infos

    Phys. Rev. E, 76(1): 011921, 2007. Cf. aussi cond-mat/0702340.
    Choisi pour le Virtual Journal of Biological Physics Research.

     


  •  

    Aggregation and vesiculation of membrane proteins by curvature-mediated interactions

    Benedict J. Reynwar, Gregoria Illya, Vagelis A. Harmandaris, Martin Michael Müller, Kurt Kremer, Markus Deserno

    Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well as create membrane curvature, and trigger tubulation when added to synthetic liposomes. Because the energy needed for such large-scale changes in membrane geometry significantly exceeds the binding energy between individual proteins and between protein and membrane, cooperative action is essential. It has recently been suggested that curvature-mediated attractive interactions could aid cooperation and complement the effects of specific binding events on membrane remodelling. But it is difficult to experimentally isolate curvature-mediated interactions from direct attractions between proteins. Moreover, approximate theories predict repulsion between isotropically curving proteins. Here we use coarse-grained membrane simulations to show that curvature-inducing model proteins adsorbed on lipid bilayer membranes can experience attractive interactions that arise purely as a result of membrane curvature. We find that once a minimal local bending is realized, the effect robustly drives protein cluster formation and subsequent transformation into vesicles with radii that correlate with the local curvature imprint. Owing to its universal nature, curvature-mediated attraction can operate even between proteins lacking any specific interactions, such as newly synthesized and still immature membrane proteins in the endoplasmic reticulum.

     Fermer     Plus d'infos

    Nature 447(7143): pp. 461-464, 2007.

     


  •  

    How to determine local elastic properties of lipid bilayer membranes from atomic-force-microscope measurements: A theoretical analysis

    Davood Norouzi, Martin Michael Müller, Markus Deserno

    Measurements with an atomic force microscope (AFM) offer a direct way to probe elastic properties of lipid bilayer membranes locally: provided the underlying stress-strain relation is known, material parameters such as surface tension or bending rigidity may be deduced. In a recent experiment a pore-spanning membrane was poked with an AFM tip, yielding a linear behavior of the force-indentation curves. A theoretical model for this case is presented here which describes these curves in the framework of Helfrich theory. The linear behavior of the measurements is reproduced if one neglects the influence of adhesion between tip and membrane. Including it via an adhesion balance changes the situation significantly: force-distance curves cease to be linear, hysteresis and nonzero detachment forces can show up. The characteristics of this rich scenario are discussed in detail in this article.

     Fermer     Plus d'infos

    Phys. Rev. E, 74(6): 061914, 2006. Cf. aussi cond-mat/0602662.
    Choisi pour le Virtual Journal of Biological Physics Research.

     


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    Mechanical Properties of Pore-Spanning Lipid Bilayers Probed by Atomic Force Microscopy

    Siegfried Steltenkamp, Martin Michael Müller, Markus Deserno, Christian Hennesthal, Claudia Steinem, Andreas Janshoff

    Résumé     Plus d'infos

    Biophys. J., 91(1): pp. 217-226, 2006.

     


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    Interface mediated interactions between particles -- a geometrical approach

    Martin Michael Müller, Markus Deserno, Jemal Guven

    Résumé     Plus d'infos

    Phys. Rev. E, 72(6): 061407, 2005. Cf. aussi cond-mat/0506019.
    Choisi pour le Virtual Journal of Biological Physics Research.

     


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    Geometry of surface-mediated interactions

    Martin Michael Müller, Markus Deserno, Jemal Guven

    Résumé     Plus d'infos

    Europhys. Lett., 69(3): pp. 482-488, 2005. Cf. aussi cond-mat/0409043.

     


 

 

2. Livres

 

  • New Trends in the Physics and Mechanics of Biological Systems
    Lecture Notes of the Les Houches Summer School, vol. 92 (Oxford University Press, 2011),
    éd. par Martine Ben Amar, Alain Goriely, Martin Michael Müller et Leticia Cugliandolo.

    Chapitre 9 :
    The physics of the cell membrane
    Martin Michael Müller et Martine Ben Amar.

 

 


 

 

3. Mémoires

  • Theoretical examinations of interface mediated interactions between colloidal particles, mémoire (2004).
  •  

  • Theoretical studies of fluid membrane mechanics, thèse de doctorat (2007).


  • Symmetry breaking in bioelasticity, thèse d'habilitation à diriger des recherches (2015).

 

 

 
     

 

     © Martin Michael Müller