Publications (en anglais)
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Articles scientifiques
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Livres
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Mémoires
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1. Articles scientifiques
 | Conformational Space of the Translocation Domain of Botulinum Toxin: Atomistic Modeling and Mesoscopic
Description of the Coiled-Coil Helix Bundle
Alexandre Delort, Grazia Cottone, Thérèse E. Malliavin, Martin Michael Müller |
Résumé
Int. J. Mol. Sci., 25: 2481, 2024.
 | Flexoelectric fluid membrane vesicles in spherical confinement
Niloufar Abtahi, Lila Bouzar, Nadia Saidi-Amroun, Martin Michael Müller |
The morphology of spherically confined flexoelectric fluid membrane vesicles in an ex-
ternal uniform electric field is studied numerically. Due to the deformations induced by
the confinement, the membrane becomes polarized resulting in an interaction with the
external field. The equilibrium shapes of the vesicle without electric field can be clas-
sified in a geometrical phase diagram as a function of scaled area and reduced volume
[1, 2]. When the area of the membrane is only slightly larger than the area of the con-
fining sphere, a single axisymmetric invagination appears. A non-vanishing electric field
induces an additional elongation of the confined vesicle which is either perpendicular or
parallel depending on the sign of the electric field parameter. Higher values of the surface
area or the electric field parameter can reduce the symmetry of the system leading to
more complex folding. We present the resulting shapes and show that transition lines
are shifted in the presence of an electric field. The obtained folding patterns could be of
interest for biophysical and technological applications alike.
 Fermer
Plus d'infos
EPL, 131(1): 18001, 2020. Cf. aussi arXiv:2006.04475.
 | Isometric bending requires local constraints on free edges
Jemal Guven, Martin Michael Müller, Pablo Vázquez-Montejo |
Résumé
Plus d'infos
Math. Mech. Solids, 24: 4051, 2019. Cf. aussi arXiv:1904.05855.
 | Helical Superstructure of Intermediate Filaments
Lila Bouzar, Martin Michael Müller, René Messina, Bernd Nöding, Sarah Köster, Hervé Mohrbach, Igor M. Kulić |
Résumé
Plus d'infos
Phys. Rev. Lett., 122: 098101, 2019. Cf. aussi arXiv:1803.04691.
 | Vesicle dynamics in confined steady and harmonically modulated Poiseuille flows
Zakaria Boujja, Chaouqi Misbah, Hamid Ez-Zahraouy, Abdelilah Benyoussef, Thomas John, Christian Wagner, Martin Michael Müller |
Résumé
Phys. Rev. E, 98: 043111, 2018. Cf. aussi arXiv:1810.04500.
 | Confining a fluid membrane vesicle of toroidal topology in an adhesive hard sphere
Lila Bouzar, Ferhat Menas, Martin Michael Müller |
Résumé
Plus d'infos
IOP Conf. Series: MSE, 186: 012021, 2017.
 | Squeezed helical elastica
Lila Bouzar, Martin Michael Müller, Pierre Gosselin, Igor M. Kulić, Hervé Mohrbach |
Résumé
Plus d'infos
Eur. Phys. J. E, 39: 114, 2016. Cf. aussi arXiv:1606.03611.
 | How bio-filaments twist membranes
Julien Fierling, Albert Johner, Igor M. Kulić, Hervé Mohrbach, Martin Michael Müller |
Résumé
Soft Matter, 12: 5747, 2016.
 | Toroidal membrane vesicles in spherical confinement
Lila Bouzar, Ferhat Menas, Martin Michael Müller |
Résumé
Plus d'infos
Phys. Rev. E, 92: 032721, 2015. Cf. aussi arXiv:1509.00765.
 | Non-linear buckling and symmetry breaking of a soft elastic sheet sliding on a cylindrical substrate
Norbert Stoop, Martin Michael Müller |
Résumé
Plus d'infos
Int. J. Non-Linear Mech., 75: 115, 2015. Cf. aussi arXiv:1503.05030.
 | Crunching Biofilament Rings
Julien Fierling, Martin Michael Müller, Hervé Mohrbach, Albert Johner, Igor M. Kulić |
Résumé
Plus d'infos
Europhys. Lett., 107(6): 68002, 2014. Cf. aussi arXiv:1408.6787.
 | Confotronic dynamics of tubular filaments
Osman Kahraman, Hervé Mohrbach, Martin Michael Müller, Igor M. Kulić |
Tubular lattices are ubiquitous in nature and technology. Microtubules and nanotubes of all
kinds act as important pillars of biological cells and the man-made nano-world. We show that
when prestress is introduced in such structures, localized conformational quasiparticles emerge and
govern the collective shape dynamics of the lattice. When coupled via cooperative interactions these
quasiparticles form larger-scale quasipolymer superstructures exhibiting collective dynamic modes
and giving rise to a hallmark behavior radically different from semiflexible beams.
Fermer
Plus d'infos
Soft Matter, 10(16): pp. 2836-2847, 2014. Cf. aussi arXiv:1312.3106.
 | Whirling skirts and rotating cones
Jemal Guven, J. A. Hanna, Martin Michael Müller |
Résumé
New J. Phys., 15: 113055, 2013. Cf. aussi arXiv:1306.2619.
 | Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo
Leonela Amoasii, Karim Hnia, Gaëtan Chicanne, Andreas Brech, Belinda Simone Cowling, Martin Michael Müller, Yannick Schwab, Pascale Koebel, Arnaud Ferry, Bernard Payrastre, Jocelyn Laporte |
Résumé
J. Cell Sci., 126(8): 1806, 2013.
 | Dipoles in thin sheets
Jemal Guven, J. A. Hanna, Osman Kahraman, Martin Michael Müller |
A flat elastic sheet may contain pointlike conical singularities that carry a metrical "charge" of Gaussian curvature. Adding such elementary defects to a sheet allows one to make many shapes, in a manner broadly
analogous to the familiar multipole construction in electrostatics. However, here the underlying field theory is non-linear,
and superposition of intrinsic defects is non-trivial as it must respect the immersion of the resulting surface in three
dimensions. We consider a "charge-neutral" dipole composed of two conical singularities of opposite sign.
Unlike the relatively simple electrostatic case, here there are two distinct stable minima and an infinity of unstable equilibria.
We determine the shapes of the minima and evaluate their energies in the thin-sheet regime where bending dominates
over stretching. Our predictions are in surprisingly good agreement with experiments on paper sheets.
Fermer
Plus d'infos
Eur. Phys. J. E, 36: 106, 2013. Cf. aussi arXiv:1212.3262.
 | Fluid membrane vesicles in confinement
Osman Kahraman, Norbert Stoop, Martin Michael Müller |
Résumé
Plus d'infos
New J. Phys., 14: 095021, 2012.
 | Petal shapes of sympetaleous flowers: the interplay between growth, geometry and elasticity
Martine Ben Amar, Martin Michael Müller, Miguel Trejo |
Résumé
Plus d'infos
New J. Phys., 14: 085014, 2012. Choisi pour les Highlights of 2012.
 | Morphogenesis of membrane invaginations in spherical confinement
Osman Kahraman, Norbert Stoop, Martin Michael Müller |
Résumé
Plus d'infos
Europhys. Lett., 97(6): 68008, 2012. Cf. aussi arXiv:1201.2518.
 | Conical instabilities on paper
Jemal Guven, Martin Michael Müller, Pablo Vázquez-Montejo |
Résumé
Plus d'infos
J. Phys. A: Math. Theor., 45(1): 015203, 2012. Cf. aussi arXiv:1107.5008.
 | Interface-mediated interactions: Entropic forces of curved membranes
Pierre Gosselin, Hervé Mohrbach, Martin Michael Müller |
Résumé
Plus d'infos
Phys. Rev. E, 83(5): 051921, 2011. Cf. aussi arXiv:1011.1221.
 | Self-Contact and Instabilities in the Anisotropic Growth of Elastic Membranes
Norbert Stoop, Falk K. Wittel, Martine Ben Amar, Martin Michael Müller, Hans J. Herrmann |
Résumé
Plus d'infos
Phys. Rev. Lett., 105(6): 068101, 2010. Cf. aussi arXiv:1007.1871.
 | Cell Model Approach to Membrane Mediated Protein Interactions
Martin Michael Müller, Markus Deserno |
Résumé
Plus d'infos
Prog. Theor. Phys. Suppl., 184: pp. 351-363, 2010.
 | Hamiltonian formulation of surfaces with constant Gaussian curvature
Miguel Trejo, Martine Ben Amar, Martin Michael Müller |
Résumé
Plus d'infos
J. Phys. A: Math. Theor., 42(42): 425204, 2009.
 | Local Membrane Mechanics of Pore-Spanning Bilayers
Ingo Mey, Milena Stephan, Eva K. Schmitt, Martin Michael Müller, Martine Ben Amar, Claudia Steinem, Andreas Janshoff |
The mechanical behavior of lipid bilayers spanning the pores of highly ordered porous silicon substrates was studied by local indentation experiments as a function of surface functionalization, lipid composition, solvent content, indentation velocity, and pore radius. Solvent-containing nanoblack lipid membranes (nano-BLMs) as well as solvent-free pore-spanning bilayers were imaged by fluorescence and atomic force microscopy prior to force curve acquisition, which allows distinguishing between membrane-covered and uncovered pores. Force indentation curves on pore-spanning bilayers attached to functionalized hydrophobic porous silicon substrates reveal a predominately linear response that is mainly attributed to prestress in the membranes. This is in agreement with the observation that indentation leads to membrane lysis well below 5% area dilatation. However, membrane bending and lateral tension dominates over
prestress and stretching if solvent-free supported membranes obtained from spreading giant liposomes on hydrophilic porous silicon are indented.
Fermer
Plus d'infos
J. Am. Chem. Soc., 131(20): pp. 7031-7039, 2009.
 | Elasticity Mapping of Pore-Suspending Native Cell Membranes
Bärbel Lorenz, Ingo Mey, Siegfried Steltenkamp, Tamir Fine, Christina Rommel, Martin Michael Müller, Alexander Maiwald, Joachim Wegener, Claudia Steinem, Andreas Janshoff |
The mechanics of cellular membranes is governed by a non-equilibrium composite framework
consisting of the semiflexible filamentous cytoskeleton and extracellular matrix proteins linked to
the lipid bilayer. While elasticity information of plasma membranes has mainly been obtained from
whole cell analysis, techniques that allow to address local mechanical properties of cell
membranes are desirable to learn how their lipid and protein composition is reflected in the elastic
behavior on local length scales. Here, we introduce an approach based on basolateral
membranes of polar epithelial Madin-Darby canine kidney (MDCK) II cells, prepared on a highly ordered porous substrate that
allows elastic mapping on a submicrometer length scale. A strong correlation between the
density of actin filaments and the measured membrane elasticity is found. Spatially resolved indentation experiments carried out with atomic force and fluorescence microscope permit to relate the supramolecular structure to the elasticity of cellular membranes. It is shown that the elastic response of the pore-spanning cell membranes is governed by the local bending modules rather than the lateral tension.
Fermer
Plus d'infos
Small, 5(7): pp. 832-838, 2009.
 | Conical Defects in Growing Sheets
Martin Michael Müller, Martine Ben Amar, Jemal Guven |
Résumé
Plus d'infos
Phys. Rev. Lett., 101(15): 156104, 2008. Cf. aussi arXiv:0807.1814.
 | How paper folds: bending with local constraints
Jemal Guven, Martin Michael Müller |
Résumé
Plus d'infos
J. Phys. A: Math. Theor., 41(5): 055203, 2008. Cf. aussi arXiv:0712.0978.
 | Contact lines for fluid surface adhesion
Markus Deserno, Martin Michael Müller, Jemal Guven |
Résumé
Plus d'infos
Phys. Rev. E, 76(1): 011605, 2007. Cf. aussi cond-mat/0703019.
Choisi pour le Virtual Journal of Biological Physics Research.
 | Balancing torques in membrane-mediated interactions: Exact results and
numerical illustrations
Martin Michael Müller, Markus Deserno, Jemal Guven |
Résumé
Plus d'infos
Phys. Rev. E, 76(1): 011921, 2007. Cf. aussi cond-mat/0702340.
Choisi pour le Virtual Journal of Biological Physics Research.
 | Aggregation and vesiculation of membrane proteins by curvature-mediated
interactions
Benedict J. Reynwar, Gregoria Illya, Vagelis A. Harmandaris, Martin Michael Müller, Kurt Kremer, Markus Deserno |
Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well as create membrane curvature, and trigger tubulation when added to synthetic liposomes. Because the energy needed for such large-scale changes in membrane geometry significantly exceeds the binding energy between individual proteins and between protein and membrane, cooperative action is essential. It has recently been suggested that curvature-mediated attractive interactions could aid cooperation and complement the effects of specific binding events on membrane remodelling. But it is difficult to experimentally isolate curvature-mediated interactions from direct attractions between proteins. Moreover, approximate theories predict repulsion between isotropically curving proteins. Here we use coarse-grained membrane simulations to show that curvature-inducing model proteins adsorbed on lipid bilayer membranes can experience attractive interactions that arise purely as a result of membrane curvature. We find that once a minimal local bending is realized, the effect robustly drives protein cluster formation and subsequent transformation into vesicles with radii that correlate with the local curvature imprint. Owing to its universal nature, curvature-mediated attraction can operate even between proteins lacking any specific interactions, such as newly synthesized and still immature membrane proteins in the endoplasmic reticulum.
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Plus d'infos
Nature 447(7143): pp. 461-464, 2007.
 | How to determine local elastic properties of lipid bilayer membranes
from atomic-force-microscope measurements: A theoretical analysis
Davood Norouzi, Martin Michael Müller, Markus Deserno |
Résumé
Plus d'infos
Phys. Rev. E, 74(6): 061914, 2006. Cf. aussi cond-mat/0602662.
Choisi pour le Virtual Journal of Biological Physics Research.
 | Mechanical Properties of Pore-Spanning Lipid Bilayers Probed by Atomic Force Microscopy
Siegfried Steltenkamp, Martin Michael Müller, Markus Deserno, Christian Hennesthal, Claudia Steinem, Andreas Janshoff |
We measure the elastic response of a free-standing lipid membrane to a local indentation by using an atomic force microscope. Starting point is a planar
gold-coated alumina substrate with a chemisorbed 3-mercaptopropionic acid
monolayer displaying circular pores of very well defined and tunable size, over
which bilayers composed of N,N,- dimethyl- N,N,- dioctadecylammonium bromide or
1,2 - dioleoyl - 3 - trimethylammonium - propane chloride were spread.
Centrally indenting these 'nanodrums' with an atomic force microscope tip yields
force-indentation curves, which we quantitatively analyze by solving the
corresponding shape equations of continuum curvature elasticity. Since the
measured response depends in a known way on the system geometry (pore size, tip
radius) and on material parameters (bending modulus, lateral tension), this opens
the possibility to monitor local elastic properties of lipid membranes in a
well-controlled setting.
Fermer
Plus d'infos
Biophys. J., 91(1): pp. 217-226, 2006.
 | Interface mediated interactions between particles -- a geometrical approach
Martin Michael Müller, Markus Deserno, Jemal Guven |
Résumé
Plus d'infos
Phys. Rev. E, 72(6): 061407, 2005. Cf. aussi cond-mat/0506019.
Choisi pour le Virtual Journal of Biological Physics Research.
 | Geometry of surface-mediated interactions
Martin Michael Müller, Markus Deserno, Jemal Guven |
Résumé
Plus d'infos
Europhys. Lett., 69(3): pp. 482-488, 2005. Cf. aussi cond-mat/0409043.
2. Livres
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New Trends in the Physics and Mechanics of Biological Systems
Lecture Notes of the Les Houches Summer School, vol. 92 (Oxford University Press, 2011),
éd. par Martine Ben Amar, Alain Goriely, Martin Michael Müller et Leticia Cugliandolo.
Chapitre 9 :
The physics of the cell membrane
Martin Michael Müller et Martine Ben Amar.
3. Mémoires
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Theoretical examinations of interface mediated interactions between colloidal particles,
mémoire (2004).
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Theoretical studies of fluid membrane mechanics, thèse de doctorat (2007).
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Symmetry breaking in bioelasticity, thèse d'habilitation à diriger des recherches (2015).
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